Enabling Formulation of Water-Soluble and Water-Insoluble Molecules Using a Lipophilic Salt Approach

September 27, 2016 - 8:00am

 

Pharmaceutical salts have traditionally been used to address formulation issues, including solubility. Preliminary in vitro and in vivo studies indicate that a lipophilic salt selection approach enables  lipid formulations by supporting substantially higher loadings—more than 10-fold in some cases—and increased solubilization in the GI tract than otherwise possible using free API. The use of lipophilic salt forms can give more APIs access to the well-established benefits of lipid formulations by overcoming certain product design constraints, such as the number and/or size of dosage unit.

This webcast will describe an approach to prepare lipophilic salt forms for a range of APIs and formulate these in concentrated lipid formulations ready for oral delivery.

 

Dr. Hywel Williams
Principal Scientist
Capsugel

Hywel D. Williams, a principal scientist at Capsugel R&D, works at the industry-academia interface with Monash Institute of Pharmaceutical Sciences and leads exploratory research in new drug delivery technologies including lipophilic salts. Hywel is a trained pharmacist, with a doctorate in pharmaceutical sciences from the University of Nottingham, UK and is an adjunct research fellow at Monash. He sits on the AAPS Lipid-Based Drug Delivery Systems Focus Group steering committee and has co-authored more than 30 research papers in drug delivery.

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Topics: 
Bioavailability Enhancement