Formulation Selection - Amorphous Dispersions & Other Tools for Drug Discovery Formulation Support

April 12, 2013
Drug Development & Delivery

Low-solubility compounds are commonly encountered in the drug discovery process. It is widely estimated that more than half of the promising small molecules identified in current drug discovery programs exhibit low solubility. Molecules with low permeability and rapid metabolism also plague discovery programs. Each of these shortcomings poses challenges for oral absorption, which must be addressed because of the prevalence of new compounds that fall into these categories. This paper describes broadly applicable formulation approaches and biomodeling tools that have been successfully used to improve the solubility and in vivo performance of low-solubility compounds.