At Bend Research, we understand that complex interrelationships between numerous variables can impact the cell-culture production process. By combining advanced tools and technologies, data integration using applied mathematics, and our multidisciplinary approach, Bend Research is able to provide critical insights that can be used to positively impact the production of biologics. Our goal is to streamline upstream processes for our clients to reduce capital and operating costs significantly through innovations in following areas, as described further down:

  • Enhanced “Observability” Using Advanced Tools and Technologies (e.g. Dielectric Spectroscopy, Raman Spectroscopy, Automatic, Aseptic Sampling System)
  • Integration of Data Sets Using Applied Mathematics and Signal Processing
  • Scale-Up and Scale-Down Guidance (e.g., Bioreactor Scale-Up/Down Model Development, Metabolic Models)

 

Watch our video on Upstream Processes:

Bend Research generates new technologies to meet the challenges of the bioprocessing industry. Offerings are broad and are tailored to specific client needs, with example capabilities and program deliverables provided below.

Enhanced “Observability” Using Advanced Tools and Technologies 
Dielectric Spectroscopy
Bend Research’s innovative use of dielectric spectroscopy technology enables automated, in situ monitoring of cell behavior beyond current commercial approaches. Coupled with models and data-analysis techniques, this approach may be used to:

 

  • aid in development-scale bioreactor experiments for design-space generation that incorporates “cell-level” observations,
  • increase process understanding at the cell level,
  • guide media development,
  • monitor cell state in larger-scale bioreactors, and
  • implement process-control strategies based on cell behavior.


Click here to download a recent Bend Research poster on dielectric spectroscopy research: "A Novel Dielectric Spectroscopy Methodology to Monitor Cell State."

 
Automated, Aseptic Sampling System
Bend Research’s Automated, Aseptic Sampling System, currently in beta testing phase, has been proven to reduce manual labor, improve data quality and increase data sets, and  improve cell health and productivity. Additional benefits of the system include:

  • minimized operator involvement,
  • minimized operator exposure,
  • significant reduction in the broth volume required for the sampling process, and
  • support for implementation of process-control strategies.

In addition to the pilot-scale system, Bend Research is continuously developing additional sampling technologies.  Click here to learn more about Bend Research's Automated, Aseptic Sampling System.

Integration of Data Sets using Applied Mathematics and Signal Processing
Bend Research provides advanced guidance to enhanced manufacturing processes through the use of integrated data management, the application of novel and existing bioreactor monitoring technologies to existing bioreactor processes, and applied mathematics. Benefits include:

  • more data and a deeper scope of “observability,” achieved through enhanced bioreactor systems, and analytical devices and methods;
  • reduction of large and numerous datasets into useful guidance through the application of key process understanding tools, models, flowcharts and applied mathematics; and
  • improved bioreactor process operations and support for bioprocess strategy development.


Click here to download a recent Bend Research poster on data integration capabilities: "Data Integration Methodology that Leverages Coupled Bioreactor Monitoring Tools, Automated Sampling, and Applied Mathematics To Redefine Bioreactor Operation."


Scale-Up and Scale-Down Guidance
Because the fundamental physics of systems vary with changing scales, Bend Research assists clients with understanding the physics of scale required to produce the same product economically at different quantities. Bend Research’s bioreactor modeling capabilities can effectively and scientifically guide process development, scale-up, and technology-transfer decisions early in development. Example deliverables include:

  • models that predict scale-up effects,
  • user interfaces for models that allow easy implementation of results, and
  • guidance for operation and design decisions for a variety of unit operations.


Click here to download a recent Bend Research poster on modeling capabilities: "Modeling a Cell-Culture Process between Shake Flask and Stirred-Tank Bioreactor, Shear Considerations on Early Stage Scale-Up."

Contact us to discuss your bioprocessing needs.